Table 1.
Characteristics of the study population (n = 48)
| All population | MCI due to AD | MCI not due to AD | t-value | pa | ||
|---|---|---|---|---|---|---|
| Age (years) (mean ± SD) | 74.6 ± 7.8 | 76.0 ± 7.8 | 73.0 ± 7.5 | −1.33 | 0.19 | |
| Sex (men) (n, %) | 21 | 44.0 | 13 (52) | 8 (35) | 1.20 | 0.23 |
| ADL (Katz’s scale) (mean ± SD) | 5.3 ± 1.3 | 5.1 ± 1.4 | 5.4 ± 1.2 | 0.72 | 0.47 | |
| IADL (Lawton’s scale) (mean ± SD) | 5.1 ± 2.6 | 4.6 ± 2.6 | 5.7 ± 2.6 | 1.46 | 0.15 | |
| MMSE (mean ± SD) | 26.0 ± 2.0 | 24.7 ± 0.7 | 27.0 ± 1.0 | 1.30 | 0.20 | |
| Alterated Clock Drawing Test (CDT) (n, %) | 29 | 61.0 | 18 (72) | 11 (47) | −2.72 | 0.03 |
| NPI (mean ± SD) | 6.9 ± 5.9 | 9.4 ± 6.6 | 4.2 ± 3.6 | −3.40 | 0.006 | |
| NPI (crude value), (n,%) | ||||||
| 2 | 16 | 33.33 | 5 (31) | 11 (79) | ||
| 3 | 4 | 8.33 | 1 (25) | 3 (75) | ||
| 4 | 5 | 10.42 | 3 (60) | 2 40) | ||
| 6 | 6 | 12.50 | 2 (33) | 4 (67) | ||
| 8 | 5 | 10.42 | 3 (60) | 2 (40) | ||
| 12 | 5 | 10.42 | 5 (100) | 0 | ||
| 18 | 6 | 12.50 | 5 (83) | 1 (17) | ||
| 24 | 1 | 2.08 | 1 (100) | 0 | ||
| SPPB score (mean ± SD) | 9.0 ± 2.6 | 9.0 ± 2.8 | 9.1 ± 2.5 | 0.0 | 0.99 | |
| Grip Strength (Kg) (mean ± SD) | 25.6 ± 7.7 | 26.6 ± 8.3 | 24.7 ± 6.9 | 1.44 | 0.39 | |
| 4-m Walking Speed (4-m WS) (m/sec) (mean ± SD) | 0.87 ± 0.5 | 0.83 ± 0.4 | 0.88 ± 0.5 | −0.61 | 0.54 | |
| Pathological Amyloid PET (n, %) | 25 | 52.0 | 25 (52) | – | ||
| Normal or Light alteration Amyloid PETb (n, %) | 23 | 48.0 | – | 23 (48) | – | |
| Cerebral Atrophy on CTc (n, %) | 26 | 54.0 | 11 (42) | 14 (56) | 1.48 | 0.15 |
| Cerebral Vascular changes on CTd (n, %) | 31 | 64.5 | 16 (51) | 9 (53) | 0.09 | 0.93 |