Table 4.
Prognostic factors of disease-free survival
| Factors | 3-year survival (%) | Univariate | Multivariate | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |||
| Primary factors | ||||||
| Location | Colon/rectum | 27.3/30.7 | 1.17 (0.67–2.10) | 0.4980 | ||
| Depth | < SS/> SS | 18.8/31.2 | 0.77 (0.23–1.91) | 0.6370 | ||
| Diff. | Diff/undiff | 31.1/0 | 3.16 (1.00–8.92) | 0.0466 | 2.14 (0.50–6.27) | 0.2650 |
| Lymphatic invasion | −/+ | 32.6/31.0 | 1.05 (0.58–1.87) | 0.7784 | ||
| Vessel invasion | −/+ | 28.0/32.7 | 0.92 (0.50–1.64) | 0.9157 | ||
| LN metastasis | −/+ | 50.7/18.4 | 1.91 (1.07–3.51) | 0.0146 | 2.03 (1.12–3.79) | 0.0186 |
| HIF-1α | −/+ | 33.3/31.2 | 1.03 (0.56–1.83) | 0.9122 | ||
| Metastatic factors | ||||||
| Meta. period | Meta/syn | 39.6/23.8 | 1.71 (0.97–3.13) | 0.0693 | ||
| Tumor size (cm) | < 5/> 5 | 26.1/41.7 | 0.95 (0.52–1.86) | 0.8708 | ||
| Tumor number | < 5/> 5 | 30.8/27.8 | 1.58 (0.79–2.94) | 0.1647 | ||
| H class | H1/H2.3 | 31.3/27.9 | 1.55 (0.88–2.70) | 0.1224 | ||
| Grade | A/B.C | 37.6/22.7 | 2.02 (1.16–3.58) | 0.0119 | 2.21 (1.26–3.94) | 0.0057 |
| Adjuvant therapy | −/+ | 30.2/23.8 | 1.54 (0.96–3.34) | 0.1681 | ||
| Hepatectomy | Minor/major | 28.8/46.2 | 0.97 (0.44–1.92) | 0.9361 | ||
| HIF-1α | −/+ | 52.2/19.6 | 2.48 (1.30–5.16) | 0.0073 | 2.40 (1.25–5.01) | 0.0079 |
| CA19-9 | < 100/> 100 | 63.5/37.5 | 1.71 (0.74–4.98) | 0.5631 | ||
| CEA | < 10/> 10 | 27.6/30.1 | 1.19 (0.66–2.20) | 0.5739 | ||
Diff differentiated type, undiff undifferentiated type, LN lymph node, SS subserous, Meta metachronous, Syn synchronous, HR hazard ratio, CI confidence interval