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. 2020 Sep 7;18:116. doi: 10.1186/s12915-020-00844-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — TP53 mutation and expression are altered in high-grade adenoma. a Overview of TP53 expression patterns with mutation information from MSS samples. Gray represents regular expression, light blue corresponds to nuclear accumulation, and dark blue is a loss of expression. See the “Methods” section for grading of TP53 staining. b Representative H&E and immunohistochemistry (IHC) images of TP53 expression in samples with low-grade (AC36) and high-grade (AC33) adenomas. H&E squares in the left-hand panels are magnified in the middle panel. c Location of mutations within the TP53 gene along with the expression/staining pattern. TAM, transactivation motif (figure is made using MutationMapper Cbioportal)