Table 2.

Significantly dysregulated miRNAs in ZZ plasma-derived EVs

Up-regulated	Fold change	Down-regulated	Fold change
hsa-miR-125a-5p.hsa-mir-125a	5.36697164	hsa-miR-658.hsa-mir-658	−5.9859744
hsa-miR-125b-5p.hsa-mir-125b-1	5.18329317	hsa-miR-4488.hsa-mir-4488	−3.378354
hsa-miR-125b-5p.hsa-mir-125b-2	5.18340772	hsa-miR-4800-5p.hsa-mir-4800	−3.8837823
hsa-miR-139-5p.hsa-mir-139	3.30934504	hsa-miR-324-5p.hsa-mir-324	−3.1512944
hsa-miR-151a-5p.hsa-mir-151a	3.45601808	hsa-miR-3656.hsa-mir-3656	−2.9581834
hsa-miR-151b.hsa-mir-151b	3.61474378	hsa-miR-6809-5p.hsa-mir-6809	−6.8978544
hsa-miR-30c-5p.hsa-mir-30c-1	2.59281873	hsa-miR-4516.hsa-mir-4516	−3.2291639
hsa-miR-30c-5p.hsa-mir-30c-2	2.59370236	hsa-miR-218-5p.hsa-mir-218-1	−3.3050034
hsa-miR-335-3p.hsa-mir-335	5.55148985	hsa-miR-218-5p.hsa-mir-218-2	−3.3052121
hsa-miR-339-5p.hsa-mir-339	5.07518785	hsa-miR-6867-5p.hsa-mir-6867	−3.8457938
hsa-miR-340-3p.hsa-mir-340	3.22016136	hsa-miR-451a.hsa-mir-451a	−2.6098699
hsa-miR-128-3p.hsa-mir-128-1	2.5067686	hsa-miR-6510-5p.hsa-mir-6510	−6.6429613
hsa-miR-328-3p.hsa-mir-328	4.1125644	hsa-miR-96-5p.hsa-mir-96	−2.506894
hsa-miR-99a-5p.hsa-mir-99a	2.78701394	hsa-miR-936.hsa-mir-936	−6.7286907
hsa-miR-191-3p.hsa-mir-191	3.57966715	hsa-miR-16-5p.hsa-mir-16-2	− 1.9759375
hsa-miR-128-3p.hsa-mir-128-2	2.29874622	hsa-miR-4793-5p.hsa-mir-4793	−4.5613285
hsa-miR-4433b-5p.hsa-mir-4433b	5.40370557	hsa-miR-4298.hsa-mir-4298	−4.1782314
hsa-miR-4446-3p.hsa-mir-4446	3.07252979	hsa-miR-16-5p.hsa-mir-16-1	−1.9774818
hsa-miR-130b-5p.hsa-mir-130b	7.72943936	hsa-miR-4306.hsa-mir-4306	−2.9663986
hsa-miR-222-3p.hsa-mir-222	2.17946999	hsa-miR-15b-5p.hsa-mir-15b	−2.1452906
hsa-miR-26b-3p.hsa-mir-26b	4.44725049	hsa-miR-106b-5p.hsa-mir-106b	−2.0233933
hsa-miR-150-5p.hsa-mir-150	3.4166121
hsa-miR-3615.hsa-mir-3615	2.17274498

Positive and negative values for Log₂(FC) represent miRNAs up-regulated or down-regulated, respectively, in ZZ individuals