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. 2020 Sep 7;8:158. doi: 10.1186/s40478-020-01028-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Age-related motor impairment in Drosophila co-expressing DPRs. a–d Median climbing speed of adult Drosophila co-expressing DPRs under the control of a single copy of the pan-neuronal driver nSyb-Gal4 (nSyb-Gal4/+) at 7 days post-eclosion. e–h Median speed of adult Drosophila co-expressing DPRs under the control of a single copy of the pan-neuronal driver nSyb-Gal4 (nSyb-Gal4/+) at 28 days post-eclosion. Error bars = SEM. ANOVA with post hoc Tukey’s multiple comparison between groups ****p < .0001; ***p < .001; **p < .01; *p < .05. Each point represents an individual fly. Motor assays were performed from at least 3 independent crosses per genotype