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. 2020 Sep 7;8:158. doi: 10.1186/s40478-020-01028-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Age-related motor impairment in Drosophila pan-neuronally expressing DPRs. a Median climbing speed of adult Drosophila pan-neuronally expressing (nSyb-Gal4) either AP1000, GA1000, PR1000, GR1000 or mCD8-GFP controls. Outcrossed Canton S flies were used as wild type controls. Flies were assayed at 3, 7, 14, 21, 28 and 42 days post-eclosion. Error bars = SEM. At day 3 a minimum of 10 flies per genotype were assayed. The minimum number of flies at any time point was 7, resulting from lethality during the time course. For full Ns per time point see the Additional file 1: Online resource 8. b Median speed of adult Drosophila pan-neuronally expressing (nSyb-Gal4) either AP1000-GFP, GA1000-GFP, PR1000-GFP, GR1000-GFP or mCD8-GFP or outcrossed Canton S wild type controls at 7 and 28 days post-eclosion. Error bars = SEM. ANOVA with post hoc Dunnett’s multiple comparison to wild type controls ****p < .0001; *p < .05 and Tukey’s multiple comparison between groups (time points) ^####p < .0001; ##p < .01. N’s are shown on the graph. Flies for motor assays were from at least 3 independent crosses per genotype