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. 2020 Sep 7;18:143. doi: 10.1186/s12964-020-00646-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Fzd7 is associated with mesenchymal phenotype. a and b Heat maps generated from CCLE database (a) and GSE12777 database (b) demonstrated the correlation of FZD7 with mesenchymal-related genes and epithelial-related genes in human BC cell lines. c Expression of Fzd7 was detected in some representative cell lines by Western blot. d and e Expression of Fzd7, Vimentin, E-cadherin, Slug and Zeb1 was detected in MDA-MB-231 cells (d) and Hs578T cells (e) transfected with shCtrl or shFZD7 by Western blot. f Expression of Vimentin was detected in MDA-MB-231 cells transfected with shCtrl or shFZD7 by Immunofluorescence staining. g Morphology of MDA-MB-231 cells transfected with shCtrl or shFZD7 was shown. h Morphology of MCF7 cells transfected with control vector or FZD7 overexpression vector was shown. i Migration of Hs578T cells transfected with shCtrl or shFZD7 was analyzed by Wound healing. j Invasion of MCF7 cells transfected with control vector or FZD7 overexpression vector was analyzed by Transwell. All experiments were carried out three times