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. 2020 Sep 7;18:143. doi: 10.1186/s12964-020-00646-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Fzd7 contributes to BC cell stemness. a and b Heat maps generated from CCLE database (a) and GSE12777 database (b) demonstrated the correlation of FZD7 with stemness-related genes in human BC cell lines. c Heat map generated from GSE2603 database demonstrated the correlation of FZD7 with stemness-related genes in human BC tissues. d Mammosphere formation in MDA-MB-231 cells transfected with shCtrl or shFZD7 was shown. e Mammosphere formation in MCF7 cells transfected with control vector or FZD7 overexpression vector was shown. f The fraction of Lgr5⁺ subpopulation in MDA-MB-231 cells transfected with shCtrl or shFZD7 was determined by flowcytometry. g The fraction of Lgr5⁺ subpopulation in MCF7 cells transfected with control vector or FZD7 overexpression vector was determined by flowcytometry. All experiments were carried out three times. Data are expressed as Mean ± s.e.m