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. 2020 Sep 7;18:143. doi: 10.1186/s12964-020-00646-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Fzd7 knockdown suppresses BC tumorigenesis and metastasis. a Growth curves of xenograft tumors derived from MDA-MB-231 cells transfected with shCtrl or shFZD7 were shown (8 mice in each group). b Tumors were harvested and weighed 10 weeks post-inoculation. c Latent periods of xenograft tumors were compared between two groups. d Expression of Ki67 and cleaved caspase-3 (Cl-caspase3) in xenograft tumors was determined by Immunohistochemistry. Ki67-positive cells and cleaved caspase-3 -positive cells were quantified. e Macro-metastasis on mouse lung surface was shown. The numbers of lung macro-metastasis were counted. f Lung metastasis was shown by HE staining. Data are expressed as Mean ± s.e.m