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. 2020 Sep 7;18:143. doi: 10.1186/s12964-020-00646-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Col6a1 is implicated in Fzd7 signaling. a and b Interrogation of CCLE database (a) and GSE12777 database (b) showed the correlation of FZD7 and WNT5B with COL6A1 in BC cell lines. c Interrogation of GSE2603 database showed the correlation of FZD7 and WNT5B with COL6A1 in BC tissues. d Expression of Fzd7 and Col6a1 in BC tissues was detected by Immunohistochemistry. #1, #2, #3 and #4 are representative specimens. e Expression of Col6a1 was detected in MDA-MB-231 cells transfected with shCtrl or shFZD7 by Western blot. f Expression of Col6a1 was detected in MDA-MB-231 cells transfected with shCtrl or shWNT5B by Western blot. g and h Expression of Col6a1, Wnt5a/b, IL-6, p-Stat3, Smad3 and Yap1 was detected in MDA-MB-231 cells (g) and Hs578T cells (h) transfected with shCtrl or shCOL6A1 by Western blot. All experiments were carried out three times