Table 1.
Patient characteristics collected within the VR FETUS study. Details of data collection form the first trimester up to 6 weeks after delivery are depicted
| Maternal Characteristics | Outcome |
| Age | Years (mean ± SD) |
| Ethnicity | Dutch/Other western/Non-western |
| Level of education | Low, middle, high |
| Postal code | |
| Medical history | Unremarkable/Diabetes/Epilepsy/Other |
| Obstetrical history | Parity, miscarriage, previous pregnancy with congenital anomaly |
| Family history | Unremarkable/family members with congenital anomaly |
| Marital status | Married/not married |
| Global household income | €0–20.000/€20.000–35.000/€35.000–65.000/>€65.000 annually |
| BMI | Kg/m2 (mean ± SD) |
| Alcohol use during first trimester | No/Yes: how many units per day? |
| Smoking during first trimester | No/yes: how many cigarettes per day |
| Recreational drug use during first trimester | No/yes: what drugs; frequency per day? |
| Folic acid use during and/or prior to pregnancy | No/yes during pregnancy/yes started prior to pregnancy |
| Pregnant after artificial reproductive technology | No/yes: what type of assisted reproduction |
| First trimester screening for aneuploidy | No/yes: result |
| Medication | No/yes: what medication, dosage, starting and stopping date? |
| Antidepressant | Never/yes currently/yes previous use |
| Questionnaires | Timing |
| Current health statusa | At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date |
| Anxiety and depressionb | At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date |
| State and trait anxietyc | At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date |
| Current health status by VASd | At inclusion, intervention or 13 weeks’ GA, 20 weeks’ GA, 6 weeks after due date |
| Medical consumptione | At 20 weeks’ GA, 32 weeks’ GA, 6 weeks after due date |
| Patient satisfaction with 3D VR | At intervention or 13 weeks’ GA, 6 weeks after due date |
| Ultrasound | Measurements |
| At inclusion, 1st trimester | Viability, CRL, multiple pregnancies, location |
| Intervention: 2D + 3D VR First Trimester Ultrasound, 1st trimester | Fetal anomaly scan using 2D and 3D VR. Growth parameters, detection of anomaly. See supplement A |
| Advanced fetal anomaly scan, 2nd trimester | Fetal anomaly scan using 2D. Growth parameters, detection of anomaly |
| Pregnancy outcome | Outcome |
| Outcome | Live birth, termination, intra-uterine fetal demise |
| Mode of delivery | Vaginal / Instrumental delivery / Cesarean section |
| Gestational age at delivery | Days (mean ± SD) |
| Invasive testing | No/yes: result |
| Date of invasive testing | |
| Neonatal outcome | Outcome |
| Birthweight | Birthweight, grams (mean ± SD) |
| Gender | Male/female |
| Congenital malformation | No/yes: what malformation |
| Prenatal diagnosis | Confirmed/discrepancy in findings: postnatal new or other findings |
aSF-36: MOS 36-item Short Form Health Survey, bHADS: Hospital Anxiety and Depression Scale, cSTAI: Spielberger State-Trait Anxiety Inventory, dVAS: visual analogue scale, eiMTA MCQ: iMTA Medical Consumption Questionnaire, CRL: Crown-Rump Length, 2D: two-dimensional, 3D VR: three-dimensional virtual reality