Table 2.
Clinical characteristics of the NF1 Cohort
| NF1 patients (n = 42) |
||
|---|---|---|
| Mean age (years) ± SD | 11.33 ± 4.25 | |
| Range | 4–20 | |
| n | (%) | |
| Gender | ||
| Male | 19 | (45.2%) |
| Female | 23 | (54.8%) |
| Clinical criteria met for NF1 | 42 | (100%) |
| OPG (Optic Pathway Glioma) | 14 | (33.3%) |
| Stable OPG on brain MRI | 11 | (78.6%) |
| Regressed OPG on brain MRI | 2 | (14.3%) |
| Worsened OPG on brain MRI | 1 | (7.1%) |
| Other CNS tumors | 5 | (11.9%) |
| Neurosurgical treatment | 2 | (40.0%) |
| Chemotherapy | 1 | (20.0%) |
| Plexiform neurofibromas (NF) | 12 | (28.6%) |
| Plexiform NF treated with surgery | 2 | (16.6%) |
| Received IQ assessment | 42 | (100%) |
| Median IQ ± SD Range | 94.32 ± 14.89 59–113 | |
| Normal IQ | 33 | (78.6%) |
| BIF | 5 | (11.9%) |
| Mild ID | 4 | (9.5%) |
| Moderate/severe ID | 0 | (0.0%) |
| Received formal psychiatric assessmen | 15 | (35.7%) |
| ASD | 0 | (0.0%) |
| ADHD | 7 | (46.6%) |
| Anxious/Depressed Disorder | 5 | (33.3%) |
| Additional support in school (i.e. IEP) | 21 | (50.0%) |
| SLD | 9 | (21.4%) |
| Low self-esteem (per parents’ report) | 15 | (35.7%) |
| Very high levels of stress in families | 14 | (33.3%) |
| Very high levels of stress between parents | 8 | (19.0%) |