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. 2020 Sep 8;32(10):108123. doi: 10.1016/j.celrep.2020.108123

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Non-uniform Targeting of PPN Inputs in MEC According to Cell Functional Properties

(A) Left: histogram of the distribution of spike widths for the entire population of recorded MEC cells. Note the clear bimodal distribution of spike widths with a minimum around the blue dashed line (spike width 240 μs) that indicates average between the two peak values and that was used to classify units as putative principal cells (pPC) and putative interneurons (pINT). Right: classification of MEC units according to spike width and firing rate criteria. Units with a spike width >240 μs and a firing rate <10 Hz were classified as pPC (gray dots), whereas the remaining units were classified as pINT (black dots). Blue dashed lines represent classification thresholds.

(B) Number of unresponsive (white) and responsive speed (blue) and non-speed (gray) cells among MEC populations of pINT (top) and pPC (bottom) following PPN stimulation. Numbers in the middle of the charts display total number of recorded cells. ^∗∗∗p < 0.001, two-proportions Z test between number of responsive pINT and pPC.

(C) Total number of responsive (blue) and unresponsive (white) pINT and pPC cells in the whole population of speed (left two bars) and non-speed (right two bars) cells recorded in MEC. Percentages above blue bars indicate proportion of responsive cells. **p < 0.01, ^∗∗∗p < 0.001, two-proportions Z test; n.s., not significant.

(D) Comparison of the number of responsive (blue) and unresponsive (white) cells for different functional populations in MEC. Percentages above blue bars indicate proportion of responsive cells in each functional cell class. ^∗p < 0.05 and ^∗∗p < 0.01, two-proportions Z test.

(E) Panels 1 and 3 from left: Circular plots displaying firing rate as a function of head direction (black line) for two representative head direction cells recorded in MEC during different screening sessions. Also represented are dwell times in each direction (blue inner line). Numbers indicate peak firing rate. Panels 2 and 4 from left: raster plots (top) and PSTH (bottom; bins, 1 ms) for the same head direction cells showing absolute changes in firing rate aligned to the onset of optogenetic laser pulses in PPN (blue shaded area) during stimulation sessions.

(F) Panels 1 and 3 from left: Path plot (gray line) with superimposed spiking activity (red dots) of two grid cells recorded in MEC during different screening sessions. Panels 2 and 4 from left: raster plots (top) and PSTH (bottom) for the same grid cells showing absolute changes in firing rate aligned to the onset of optogenetic laser pulses in PPN (blue window) during stimulation sessions (PSTH bins, 1 ms).