Figure 4.

Cross-linking GluA2 Subunit Suppresses the Expression of w-Pot in FWE Mice

(A) Time course of averaged PSP peak amplitude upon RWS (RWS, left) and when RWS is not induced (no RWS, right) in anti-GFP-injected mice.

(B) Mean (± SEM) peak amplitude before (baseline) and after RWS (n = 9 cells) or no RWS (n = 8 cells). Black lines between bars indicate pairs. ns, not significant.

(C and D) Same as in (A) and (B) but for anti-GluA2-IgG-injected mice (RWS, n = 8 cells; no RWS, n = 8 cells).

(E) Mean (± SEM) peak amplitude normalized to baseline (percentage of LTP). Triangles, individual cells.

(F) Correlation between normalized plateau strength and the level of RWS-induced w-Pot in anti-GFP- (turquoise) and anti-GluA2 (khaki) IgG-injected mice.