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. 2020 Sep 1;32(9):108097. doi: 10.1016/j.celrep.2020.108097

Figure 5.

Figure 5

w-Pot Mediates Neuronal Responses Potentiation during SWE-Induced Cortical Remapping

(A) Schematic of experimental strategy. IgG is injected during SWE, followed by washout before recordings.

(B) Left: single-cell examples of whisker-evoked responses (gray, single traces; green and purple, averaged traces from anti-GFP- and anti-GluA2-injected mice, respectively). Square pulse line, C2 whisker deflection (100 ms). Right: fraction of spiking neurons triggered by whisker deflection.

(C) PW-evoked PSP grand average (all recorded cells averaged ± SEM). Square pulse line, C2 whisker deflection (100 ms).

(D) Left: number of spikes per whisker deflection (spiking probability; median ± interquartile range). Right: median (± interquartile range) PSP peak amplitude. FWE, n = 20 cells; SWE, n = 13 cells; GFP, n = 8 cells; GluA2, n = 9 cells. ns, not significant.

(E) Time course of averaged PSP peak amplitude upon RWS in anti-GFP-injected (green) and anti-GluA2-injected (purple) mice (after washout).

(F) Left: mean (± SEM) PSP peak amplitude before (baseline) and after RWS. Black lines between bars indicate pairs. Right: mean (± SEM) amplitude normalized to baseline. Triangles, individual cells. FWE, n = 7 cells; SWE, n = 7 cells; GFP, n = 6 cells; GluA2, n = 6 cells.