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. 2020 Sep 7;11:384. doi: 10.1186/s13287-020-01902-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Effect of adipose-derived mesenchymal stem cells (ADMSCs) on systemic inflammatory response in rats with cecal ligation and puncture (CLP)-induced acute lung injury (ALI). The serum levels of IL-6 (a) and TNF-α (b) were measured using enzyme-linked immunosorbent assay (ELISA). *Compared with the sham control (SC) group; ^#compared with the CLP group; *, ^#P < 0.05; **, ^##P < 0.01; ***, ^###P < 0.001. c Effect of CLP and ADMSCs on 24-h lung histology. Hematoxylin and eosin staining showed that inflammatory infiltration, edema, and hemorrhage of rat lung tissue from the CLP group were significantly enhanced. Treatment with ADMSCs improved these anomalies (bar = 100 μm)