Table 3.

Time measurements for a single SC trastuzumab injection.

Time in minutes [SD]	Home-based administration (n = 29)		Hospital-based administration (n = 39)		Difference	P-valuec
	Mean	SD	Mean	SD
Patient
Time stayed at home for injection	62.1	53.4	n/a	n/a
Time spent in hospital (arrival to discharge)	n/a	n/a	45.5	42.2
Length of stay day-care unit	n/a	n/a	33.1	36.7
Hospital
Total Healthcare professional time	110.2	62.9	38.3	4.8	71.9	0.004
Preparation of trastuzumab
Healthcare professional timea	n/aa	n/aa	5.8	3.1
Administration of trastuzumab
Responsible nurse	95.9	49.1	28.7	4.9	67.2	0.001
Bedside activities (time with patient)	30.7	10.8	12.6	4.9	18.1
Time with patient	26.0	10.9	6.2	4.2	19.8
Duration SC injection	4.7	1.9	6.4	1.9	−1.7	<0.001
Non-bedside activities	23.9	17.3	16.1	12.4	7.7
Travel time nurse	41.3	32.8	n/a	n/a
Second nurse	1.6	1.0	0.6	0.2	1.0
Planner in hospital-based settingb	2.7	1.3	3.2	0.9	−0.5
Planner in home-based setting	2.0	3.7	n/a	n/a
Referral & reporting (between hospital & homecare organisation)	8.0	14.4	n/a	n/a
Societal
Productivity losses
Paid work (hours)	0.00	0.00	0.00	0.00	0.00
Unpaid work (hours)	0.41	1.19	0.38	0.88	0.03
Time of informal caregiver (hours)	0.31	0.97	0.94	1.13	−0.63
Distance patient's home to hospital (kilometers)	15.50	13.34	11.54	8.84	3.96
Travelling distance patient (kilometers)	n/a	n/a	23.08	17.68
Travelling distance nurse (kilometers)	26.80	28.17	n/a	n/a

SC subcutaneous; SD standard deviation.

^afor home-based administration, preparation time of the trastuzumab injection was included in costs for ready to use trastuzumab injection.

^bCosts for the time of a planner were in the hospital-based setting included within the overhead costs.

^cStatistical significance of the difference in time was assessed using non-parametric bootstrap techniques (1000 bootstraps).