FIGURE 4.

(A) Lung lactate production measured by the difference in the lactate concentration across the lungs (arteriovenous difference in lactate) in various groups of patients shows that lungs of ALI patients produce significant amounts of lactate. (B) Lung lactate production measured in 43 patients with acute injury showed that it is proportional to injury severity as determined by Murray’s lung injury score (Murray et al., 1988). (ALI, acute lung injury; CPE, acute pulmonary edema; BPN, bronchopneumonia; LTx, lung transplantation; Other, other types of respiratory failure, mEq/min.M²: mmoles per minute per square meter). Reprinted with permission of the American Thoracic Society. Copyright © 2019 American Thoracic Society from De Backer et al. (1997). The American Journal of Respiratory and Critical Care Medicine is an official journal of the American Thoracic Society. *p < 0.05 versus ALI, ⁺p < 0.01 versus ALI.