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. 2020 Aug 6;21(13):903–917. doi: 10.2217/pgs-2020-0045

Table 5. . Conditional analysis.

(A) Target SNPs based on Gal rs1893679 as test SNP
Rank SNP Gene Chr Location Stat p0 p-value
1 rs4518200 NPY1R 4 Intronic 23.2618 0.0007 0.0773
2 rs4691075 NPY1R 4 Intronic 23.1614 0.0006 0.0802
3 rs4691910 NPY1R 4 Intronic 23.1614 0.0006 0.0802
4 rs2271933 HCRTR1 1 Missense variant 13.9442 0.0362 0.9521
5 rs4057797 NPY1R 4 Intronic 13.6604 0.0342 0.9659
6 rs2270465 OXTR 3 24KB upstream 13.0031 0.0545 0.9847
7 rs237902 OXTR 3 Synonymous variant 11.7492 0.0828 0.9988
8 rs1715747 CRHBP 5 Intronic 11.5460 0.0778 0.9993
9 rs17339455 NR3C1 5 Intronic 11.4218 0.1039 0.9996
10 rs6596189 PITX1 5 Intronic 11.3565 0.0554 0.9996
There is no significant result but three NPY1R variants with p < 0.10 will be used as new test SNPs.
(B) Target SNPs based on NPY1R rs4691910 as test SNP
Rank SNP Gene Chr Location Stat p0 p-value
1 rs1893679 GAL 11 2KB upstream variant 25.7254 0.0005 0.0162
2 rs3136541 GAL 11 Intronic 23.5334 0.0008 0.0429
3 rs33933482 AVPR1B 1 3′-UTR 14.860 0.0100 0.8000
4 rs10474485 CRHBP 5 Intronic 14.173 0.0235 0.8792
5 rs17339455 NR3C1 5 Intronic 13.6313 0.0241 0.9260
6 rs1715747 CRHBP 5 Intronic 12.8612 0.0653 0.9707
7 rs1500 CRNBP 5 Noncoding transcript variant 12.0178 0.0907 0.9904
8 rs2271933 HCRTR1 1 Missense variant 10.7242 0.1371 0.9982
9 rs1893219 MC2R 18 2KB upstream variant 10.1073 0.1747 0.9995
10 rs2270007 CRHR2 7 Intronic 9.9015 0.0987 0.9997
Two GAL SNPs identified as significant target SNPs, rs1893679 and rs3136541.
(C) Target SNPs based on GALR1 rs9807208 as test SNP
Rank SNP Gene Chr Location Stat p0 p-value
1 rs3136541 GAL 11 Intronic 33.3614 0.0001 0.0013
2 rs2918419 NR3C1 5 Intronic 19.6198 0.0059 0.2886
3 rs1893679 GAL 11 2KB upstream variant 17.021 0.0116 0.6115
4 rs973002 CRHR2 7 Intronic 15.2123 0.0254 0.8489
5 rs2270007 CRHR2 7 Intronic 15.0375 0.0275 0.866
6 rs11099680 NR3C2 4 Intronic 12.5715 0.0596 0.9934
7 rs5374 GALR1 18 Synonymous variant 12.4145 0.0661 0.949
8 rs1056526 HCRTR1 1 Synonymous variant 12.0884 0.0661 0.9975
9 rs2271933 HCRTR1 1 Missense variant 11.6743 0.0752 0.9991
10 rs2284217 CRHR2 7 Intronic 11.2698 0.0984 0.9996

GAL rs3136541 identified as significant target SNP. Target SNPs are listed by Stat in descending order. Bold terms indicates p < 0.50.

Chr: Chromosome number; p0. Nominal significance level; Stat: Test statistic.