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. 2020 Sep 10;11:51. doi: 10.1186/s13293-020-00327-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Bootstrap resampling to assess the stability of Hedges’ g effect size estimates. Median (black dots) and 95% confidence intervals (gray shading) of the bootstrapped effect sizes for each miRNA for the total sample at the second and third trimester time points. Separate bootstrap analysis of the median effect size of miRNA expression from pregnancies with female (red dots) or male (blue dots) fetuses is overlaid. miRNAs are arranged on the x-axis in the order of decreasing median bootstrap effect size in the composite analyses. Dotted lines indicate moderate (0.5) and large (0.8) effect size cutoffs. The table shows the number of miRNAs with sex-segregated median effect size falling outside the 95% confidence interval for the composite sample