Table 1.
NYU and OAI cohorts SKOA subject baseline demographics and imaging features
| Variable | NYU (n = 243) | OAI (n = 203) |
|---|---|---|
| Age (years) | 60.1 (10.6) | 62.8 (10.6) |
| Sex (%): | ||
| Male | 33.30% | 47.0% |
| Female | 66.70% | 53.0% |
| BMI (kg/m2) | 26.7 (3.6) | 27.3 (3.1) |
| VAS (0–100) | 42.3 (29.9) | NA |
| WOMAC (0–100) | 36.6 (24.7) | 18.5 (16.2) |
| Radiographic joint space width (JSW) (mm): | ||
| Baseline | 3.65 (1.34) | 3.62 (1.30) |
| 24 months | 3.13 (1.51) | 3.36 (1.49) |
| Radiographic osteophytes: | ||
| Medial tibial plateau (MTP) (0–3) | 0.50 (0.70) | 1.08 (1.17) |
| Medial femoral condyle (MFC) (0–3) | 0.87 (0.69) | 0.93 (1.02) |
| Lateral tibial plateau (LTP) (0–3) | 0.41 (0.64) | 0.99 (0.80) |
| Medial femoral condyle (LFC) (0–3) | 0.51 (0.60) | 0.33 (0.38) |
| MRI: | (n = 111) | (n = 46) |
| Mean medial BML WORMS score (0–15) | 1.13 (1.86) | 1.90 (2.04) |
Data shown are the mean (SD), total number or percent affected, as indicated. SKOA symptomatic knee OA, BMI body mass index, VAS visual analog scale, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index, WORMS Whole-Organ Magnetic Resonance Imaging Score, BML bone marrow lesion, NA not available. Both medial and lateral osteophytes in tibial plateau (MTP, LTP) and femoral condyle (MFC, LFC) regions scored semiquantitatively (0–3) [0 = absent, 1-mild, 2-moderate, and 3 = severe]. Subarticular bone marrow lesions (BML, a score of 0–3) were scored within the anterior, central, and posterior regions of the medial and lateral tibial plateaus; central and posterior regions of the medial and lateral femoral condyles were also scored