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. 2020 Sep 10;39:183. doi: 10.1186/s13046-020-01659-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — NEK2 silencing suppresses the growth and proliferation and induces the apoptosis of cervical cancer cells in vitro. a HeLa and SiHa cells were transfected with indicated siRNAs for 48 h, and samples were harvested and analyzed by Western blotting with the indicated antibodies (n = 3). b NEK2 silencing inhibited the growth of HeLa and SiHa cells (n = 3). c Colony formation ability was significantly reduced in NEK2-depleted cells. *** P < 0.001 (n = 3). d Knockdown of NEK2 reduced the proliferation of HeLa and SiHa cells, as determined by an EdU cell proliferation assay. ** P < 0.01, *** P < 0.001 (n = 3). Scale bar: 200 μm. e HeLa and SiHa cells transfected with indicated siRNAs for 48 h were subjected to annexin V-EGFP/propidium iodide staining, and analyzed by flow cytometry. *** P < 0.001 (n = 3)