Table 7.
Effects of sub-chronic oral administration of ICR on the hematological profile of females rats
| Females | ICR (mg/kg b.w.) | |||
|---|---|---|---|---|
| Control | 250 | 500 | 1000 | |
| White blood cells (X 103 /μL) | 18.650 ± 0.450 | 15.3000 ± 0.500 ns | 17.250 ± 1.150 ns | 18.050 ± 1.350ns |
| Lymphocytes (%) | 82.850 ± 1.750 | 84.700 ± 1.825ns | 80.570 ± 0.602 ns | 77.500 ± 0.900ns |
| Granulocytes (%) | 14.870 ± 1.365 | 10.550 ± 1.150* | 10.430 ± 1.629* | 10.700 ± 0.900* |
| Red blood cells (X 106 /μL) | 7.590 ± 0.130 | 7.160 ± 0.150ns | 7.340 ± 0.100 ns | 7.000 ± 0.040ns |
| Haemoglobin (g/dL) | 16.300 ± 0.360 | 16.130 ± 0.585ns | 16.280 ± 1.415ns | 15.750 ± 0.550 ns |
| Hematocrit (%) | 44.200 ± 2.000 | 41.130 ± 2.573ns | 41.600 ± 3.677 ns | 41.300 ± 1.500 ns |
| Mean corpuscular volume (fL) | 61.350 ± 1.450 | 59.130 ± 2.196ns | 59.050 ± 1.150 ns | 59.100 ± 1.800ns |
| Mean corpuscular Hb (pg) | 21.600 ± 0.100 | 23.130 ± 0.763ns | 23.100 ± 0.585 ns | 22.300 ± 0.700ns |
| MCHC (g/dL) | 37.200 ± 1.100 | 38.300 ± 1.200ns | 38.800 ± 1.20 ns | 38.050 ± 0.050ns |
| RDWCV (%) | 17.570 ± 0.717 | 17.430 ± 1.050ns | 17.900 ± 1.200ns | 19.250 ± 1.050ns |
| RDWSD (fL) | 44.330 ± 1.040 | 43.470 ± 1.350 ns | 46.00 ± 1.500 ns | 46.100 ± 0.050 ns |
| Platelets (X 103 /μL) | 521.00 ± 8.900 | 512.0 ± 9.800ns | 824.300 ± 6.506* | 879.500 ± 7.500* |
| Mean platelet volume (fL) | 11.400 ± 0.900 | 10.40 ± 1.411ns | 11.470 ± 1.305ns | 11.900 ± 1.229ns |
| Platelet distribution width (fL) | 11.770 ± 1.002 | 10.330 ± 1.193ns | 10.200 ± 0.900ns | 11.770 ± 1.002 ns |
| Plateletcrit (%) | 0.660 ± 0.050 | 0.585 ± 0.165ns | 0.945 ± 0.049ns | 0.943 ± 0.136ns |
Results were expressed as Mean ± SEM for n = 5 animals per group. *:Significantly different from the control at p < 0.05
MCHC Mean corpuscular Haemoglobin concentration, RDWCV Red blood cells distribution width_CV, RDWSD Red blood cells distribution width_SD, ns non significative, ICR methanol extract of the roots of Imperata cylindrica