Table 2.
Baseline characteristics
| Less than 6 cycles | Exactly 6 cycles | More than 6 cycles | Exactly 6 cycles—no PD | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PD before end of treatment (N = 567) | No PD before end of treatment (N = 584) | Total (N = 1151) | PD before end of treatment (N = 80) | No PD before end of treatment (N = 475) | Total (N = 555) | PD before end of treatment (N = 66) | No PD before end of treatment (N = 273) | Total (N = 339) | Treatment | |||||
| DOX 75 (N = 223) | DOX 50-IFO 5 (N = 80) | DOX 75-IFO 5 (N = 63) | DOX 75-IFO 10 (N = 109) | Total (N = 475) | ||||||||||
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | |
| Gender | ||||||||||||||
| Male | 273 (48.1) | 284 (48.6) | 557 (48.4) | 45 (56.3) | 226 (47.6) | 271 (48.8) | 26 (39.4) | 139 (50.9) | 165 (48.7) | 102 (45.7) | 34 (42.5) | 30 (47.6) | 60 (55.0) | 226 (47.6) |
| Female | 294 (51.9) | 299 (51.2) | 593 (51.5) | 35 (43.8) | 248 (52.2) | 283 (51.0) | 40 (60.6) | 134 (49.1) | 174 (51.3) | 121 (54.3) | 45 (56.3) | 33 (52.4) | 49 (45.0) | 248 (52.2) |
| Missing | 0 (0.0) | 1 (0.2) | 1 (0.1) | 0 (0.0) | 1 (0.2) | 1 (0.2) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.3) | 0 (0.0) | 0 (0.0) | 1 (0.2) |
| Age | ||||||||||||||
| < 40 years | 122 (21.5) | 124 (21.2) | 246 (21.4) | 26 (32.5) | 125 (26.3) | 151 (27.2) | 18 (27.3) | 80 (29.3) | 98 (28.9) | 45 (20.2) | 23 (28.8) | 26 (41.3) | 31 (28.4) | 125 (26.3) |
| 40–50 years | 137 (24.2) | 122 (20.9) | 259 (22.5) | 20 (25.0) | 115 (24.2) | 135 (24.3) | 11 (16.7) | 64 (23.4) | 75 (22.1) | 54 (24.2) | 15 (18.8) | 9 (14.3) | 37 (33.9) | 115 (24.2) |
| 50–60 years | 164 (28.9) | 170 (29.1) | 334 (29.0) | 19 (23.8) | 148 (31.2) | 167 (30.1) | 13 (19.7) | 73 (26.7) | 86 (25.4) | 77 (34.5) | 19 (23.8) | 14 (22.2) | 38 (34.9) | 148 (31.2) |
| > = 60 years | 134 (23.6) | 156 (26.7) | 290 (25.2) | 13 (16.3) | 85 (17.9) | 98 (17.7) | 16 (24.2) | 49 (17.9) | 65 (19.2) | 47 (21.1) | 21 (26.3) | 14 (22.2) | 3 (2.8) | 85 (17.9) |
| Missing | 10 (1.8) | 12 (2.1) | 22 (1.9) | 2 (2.5) | 2 (0.4) | 4 (0.7) | 8 (12.1) | 7 (2.6) | 15 (4.4) | 0 (0.0) | 2 (2.5) | 0 (0.0) | 0 (0.0) | 2 (0.4) |
| Performance status | ||||||||||||||
| PS 0 | 223 (39.3) | 265 (45.4) | 488 (42.4) | 38 (47.5) | 274 (57.7) | 312 (56.2) | 25 (37.9) | 127 (46.5) | 152 (44.8) | 132 (59.2) | 39 (48.8) | 38 (60.3) | 65 (59.6) | 274 (57.7) |
| PS 1 | 275 (48.5) | 265 (45.4) | 540 (46.9) | 34 (42.5) | 189 (39.8) | 223 (40.2) | 32 (48.5) | 120 (44.0) | 152 (44.8) | 84 (37.7) | 37 (46.3) | 24 (38.1) | 44 (40.4) | 189 (39.8) |
| PS 2 + | 67 (11.8) | 51 (8.7) | 118 (10.3) | 8 (10.0) | 11 (2.3) | 19 (3.4) | 9 (13.6) | 24 (8.8) | 33 (9.7) | 7 (3.1) | 3 (3.8) | 1 (1.6) | 0 (0.0) | 11 (2.3) |
| Missing | 2 (0.4) | 3 (0.5) | 5 (0.4) | 0 (0.0) | 1 (0.2) | 1 (0.2) | 0 (0.0) | 2 (0.7) | 2 (0.6) | 0 (0.0) | 1 (1.3) | 0 (0.0) | 0 (0.0) | 1 (0.2) |