Fig. 8.

(a) Diagrams representing rhinovirus 16 (HRV16)‐induced tissue inhibitor of metalloproteinases 1 (TIMP‐1) expression inhibited by Leonurus sibiricus extracts in Wistar Institute‐38 (WI‐38) (left panel) and human fetal lung fibroblast (HFL1) (right panel) cell lines. Rhinovirus elevated the expression of TIMP‐1, which was inhibited by transcriptional factor over‐expression‐transformed (AtPAP1 TR) in both cell lines. Data presented as relative quantity ± standard deviation (s.d.). (b) AtPAP1 TR inhibits TIMP‐1 protein expression in WI‐38 and HFL1 fibroblasts. The inhibition is presented as % of decrease of HRV16‐induced expression at a concentration of 0·312 mg/ml. Data presented as % optical density (OD) over background values. Data presented as mean ± s.d.