Table 3.
Direct and indirect effects of E-DII on incident ROA and SxOA for mediation via BMI
| E-DII | < 2.50 | ≥ 2.50 |
|---|---|---|
| ROA | n = 894 persons | n = 892 persons |
| Total effect* | 1.00 (ref) | 1.47 (1.10, 1.97) |
| Direct effect | 1.00 (ref) | 1.36 (1.02, 1.82) |
| Indirect effect via BMI | 1.00 (ref) | 1.08 (1.04, 1.13) |
| Proportion of mediation via BMI | 20.4% | |
| SxOA | n = 1471 persons | n = 1469 persons |
| Total effect* | 1.00 (ref) | 1.31 (1.13, 1.51) |
| Direct effect | 1.00 (ref) | 1.16 (1.01, 1.34) |
| Indirect effect via BMI | 1.00 (ref) | 1.13 (1.09, 1.16) |
| Proportion of mediation via BMI | 44.5% | |
E-DII energy-adjusted dietary inflammatory index, BMI body mass index, ROA radiographic knee osteoarthritis, SxOA symptomatic knee osteoarthritis
*Model adjusted for age (years), sex (men vs women), race (white vs non-white), total energy intake (kcal/day), education (< college vs ≥ college), yearly income level (< 50,000 US$ vs ≥ 50,000 US$), tobacco use (non-smoker vs smoker), and physical activity (PASE, continuous)