Table 5.
Other parameters incorporated in the model
| Parameter | Input | SA range | Distribution | References |
|---|---|---|---|---|
| Transition probability | ||||
| Normal to LGIN | 0.0000 | – | – | – |
| LGIN to normal | 0.1427 | 0.1142–0.1712 | Beta | [32–38] |
| IC to DFS_IC | 0.9363-d_nor | 0.7490–0.9363 | Beta | [17] |
| IC progress | 0.0534 | 0.0427–0.0641 | Beta | [17, 47–49] |
| SM proportion | 0.2143 | 0.1714–0.2572 | Dirichlet | Screening |
| Mod proportion | 0.5714 | 0.4571–0.6857 | Dirichlet | |
| Adv proportion | 0.2143 | 0.1714–0.2572 | Dirichlet | |
| DFS_IC to IC | 0.0069 | 0.0055–0.0083 | Beta | [50] |
| DFS_IC progress | 0.0268 | 0.0214–0.0322 | Beta | [51] |
| SM proportion | 0.5556 | 0.4445–0.6667 | Dirichlet | [51] |
| Mod proportion | 0.4444 | 0.3555–0.5333 | Dirichlet | [51] |
| Adv proportion | 0.0000 | 0.0000–0.0000 | Dirichlet | [51] |
| SM to DFS_SM | 0.9051-d_nor | 0.7241–1.0000 | Beta | [52] |
| SM progress | 0.1386 | 0.1109–0.1663 | Beta | [53, 54] |
| Mod proportion | 0.7562 | 0.6050–0.9074 | Beta | [48, 55–61] |
| Adv proportion | 0.2438 | 0.1950–0.2926 | Beta | [48, 55–61] |
| DFS_SM to SM | 0.0393 | 0.0314–0.0472 | Beta | [62] |
| DFS_SM progress | 0.0883 | 0.0706–0.1060 | Beta | [53] |
| Mod proportion | 0.7562 | 0.6050–0.9074 | Beta | [48, 55–61] |
| Adv proportion | 0.2438 | 0.1950–0.2926 | Beta | [48, 55–61] |
| Mod to DFS_Mod | 0.5930-d_nor | 0.4744–0.7116 | Beta | [63] |
| Mod to Adv | 0.0317 | 0.0254–0.0380 | Beta | [64] |
| DFS_Mod to Mod | 0.0425 | 0.0340–0.0510 | Dirichlet | [64] |
| DFS_Mod to Adv | 0.0097 | 0.0078–0.0116 | Dirichlet | [64] |
| Adv to PFS | 0.1967-d_nor | 0.1574–0.2360 | Dirichlet | [65] |
| PFS progress | 0.7002 | 0.5602–0.8402 | Dirichlet | [66] |
| RR | 0.7000 | 0.5600–0.8400 | Lognormal | [15] |
| EC state-specific death probability (age ≤ 65 years) | ||||
| SM | 0.0994 | 0.0795–0.1193 | Beta | [67] |
| DFS_SM | 0.0633 | 0.0506–0.0760 | Beta | [67] |
| Mod | 0.2988 | 0.2390–0.3586 | Beta | [54] |
| DFS_Mod | 0.1902 | 0.1522–0.2282 | Beta | [54] |
| Adv | 0.4613 | 0.3690–0.5536 | Beta | [66, 68] |
| PFS | 0.4303 | 0.3442–0.5164 | Beta | [66, 68] |
| Risk ratios of EC death probability among patients aged more than 65 years compared to patients aged less than 65 years | ||||
| RR_SM/RR_DFS_SM | 1.30 | 1.20–1.50 | Lognormal | [69] |
| RR_Mod/RR_DFS_Mod | 1.20 | 1.10–1.30 | Lognormal | [69] |
| RR_Adv/RR_PFS_Adv | 1.16 | 1.10–1.20 | Lognormal | [69] |
SA one-way sensitivity analysis, d_nor annual death probability for health individuals, which was defined as the difference between all-cause mortality and EC-related mortality