Table 2.
Effect of sildenafil on clinical and echocardiographic parameters
| Variables | Sildenafil | Control | ||
|---|---|---|---|---|
| Baseline | 6 months | Baseline | 6 months | |
| Systolic arterial pressure, mm Hg | 130 ± 14 | 133 ± 16 | 127 ± 12 | 132 ± 17 |
| Diastolic arterial pressure, mm Hg | 80 ± 11 | 79 ± 8 | 76 ± 10 | 79 ± 10 |
| Heart rate, bpm | 63 ± 8 | 62 ± 8 | 63 ± 7 | 62 ± 6 |
| Pulmonary vascular resistance, Wood units | 3.33 ± 0.64 | 2.69 ± 0.49**§§ | 3.19 ± 0.47 | 3.16 ± 0.45 |
| Acceleration time of RVOT, ms | 83 ± 17 | 114 ± 24**§§ | 87 ± 17 | 88 ± 14 |
| Pulmonary artery systolic pressure, mm Hg | 58.6 ± 14.9 | 41.6 ± 10.3**§§ | 55.5 ± 13.5 | 56.4 ± 12.4 |
| Transpulmonary gradient, mm Hg | 23.3 ± 7.7 | 12.7 ± 9.1**§§ | 22.1 ± 8.8 | 21.0 ± 7.1 |
| LV end diastolic dimension, cm | 5.30 ± 0.47 | 5.37 ± 0.51* | 5.14 ± 0.46 | 5.15 ± 0.42 |
| Interventricular septum, cm | 1.20 ± 0.10 | 1.14 ± 0.08**§§ | 1.20 ± 0.09 | 1.20 ± 0.09 |
| LV posterior wall, cm | 1.20 ± 0.10 | 1.14 ± 0.08**§§ | 1.20 ± 0.09 | 1.20 ± 0.09 |
| LV mass index, g/m2 | 135 ± 52 | 111 ± 40** | 130 ± 44 | 131 ± 47 |
| LA volume index, mL/m2 | 50.7 ± 7.4 | 44.5 ± 6.4**§§ | 49.8 ± 8.5 | 50.2 ± 8.4 |
| Mitral e′, cm/s | 6.3 ± 1.4 | 7.3 ± 1.5** | 6.7 ± 1.6 | 6.6 ± 1.4 |
| Mitral E, cm/s | 86 ± 19 | 83 ± 16 | 81 ± 16 | 83 ± 16 |
| Mitral E/e′ ratio | 14.2 ± 4.2 | 11.8 ± 3.2** | 12.6 ± 3.7 | 13.2 ± 3.8 |
| RV basal diameter, cm | 4.80 ± 0.55 | 4.50 ± 0.52** | 4.69 ± 0.56 | 4.68 ± 0.54 |
| RA volume index, mL/m2 | 45.4 ± 6.5 | 38.5 ± 6.3** | 46.6 ± 8.8 | 46.8 ± 8.6 |
| Tricuspid e′, cm/s | 8.2 ± 2.8 | 11.4 ± 2.6**§§ | 8.9 ± 2.9 | 8.4 ± 2.5 |
| Tricuspid Е/e′ ratio | 7.2 ± 3.4§ | 4.0 ± 1.4**§ | 5.3 ± 1.8 | 5.9 ± 2.2 |
| IVC size, cm | 2.26 ± 0.33 | 1.89 ± 0.37**§ | 2.08 ± 0.31 | 2.13 ± 0.35 |
| IVC collapse with a sniff, % | 34 ± 8§ | 53 ± 13**§§ | 42 ± 14 | 42 ± 13 |
| TAPSE, cm | 1.76 ± 0.38 | 2.18 ± 0.47**§ | 1.88 ± 0.37 | 1.91 ± 0.37 |
| TAPSE/PASP, mm/mm Hg | 0.32 ± 0.09 | 0.55 ± 0.17**§§ | 0.36 ± 0.13 | 0.36 ± 0.12 |
| s′RV, cm/s | 9.6 ± 2.1 | 12.2 ± 3.2**§ | 10.6 ± 2.0 | 10.7 ± 1.9 |
| NT-proBNP, pg/mL | 391 (190–582) | 416 (227–671) | 468 (205–720) | 470 (195–697) |
OT outflow tract, LA left atrial, IVC inferior vena cava, TAPSE tricuspid annular plane systolic excursion, PASP pulmonary artery systolic pressure, s′RV peak velocity at the tricuspid annulus
* — P < 0.05, ** — P < 0.01 vs baseline
§— P < 0.05, §§— P < 0.01 vs corresponding value in control group