Table 3.
Associations between the polygenic scores and pathological diagnostic categories and variables
| Pathological diagnosis | AD PHS | PD PRS | DLB PRS | |||
|---|---|---|---|---|---|---|
| RRR (95% CI) | p value | RRR (95% CI) | p value | RRR (95% CI) | p value | |
| MLR, control as reference | ||||||
| FTD | 1.60 (1.16–2.21) | .004 | 1.01 (.60–1.70) | .97 | 1.24 (.76–2.02) | .40 |
| DLB | 1.73 (1.23–2.42) | .002 | 1.39 (.80–2.41) | .24 | 3.22 (1.62–6.40) | < .001 |
| AD + DLB | 3.05 (2.47–3.77) | < .001 | .93 (.67–1.28) | .65 | 4.47 (2.76–7.22) | < .001 |
| AD | 3.06 (2.52–3.71) | < .001 | .92 (.69–1.22) | .57 | 3.08 (2.33–4.09) | < .001 |
| AD + MTLS | 3.14 (2.45–4.02) | < .001 | .95 (.65–1.39) | .78 | 2.94 (2.07–4.18) | < .001 |
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | |
|---|---|---|---|---|---|---|
| Braak stage | ||||||
| OLR, POM | – | – | 0.93 (0.82–1.05) | .24 | – | – |
| OLR, PPOM | ||||||
| I | 2.34 (1.60–3.42) | < .001 | – | – | 1.89 (1.06–3.39) | .03 |
| II | 2.10 (1.76–2.50) | < .001 | – | – | 2.05(1.52–2.76) | < .001 |
| III | 2.28 (1.99–2.62) | < .001 | – | – | 2.33 (1.88–2.89) | < .001 |
| IV | 1.88 (1.68–2.10) | < .001 | – | – | 1.95 (1.63–2.33) | < .001 |
| V | 1.53 (1.40–1.68) | < .001 | – | – | 1.50 (1.30–1.72) | < .001 |
| VI | 1.33 (1.23–1.44) | < .001 | – | – | 1.34 (1.18–1.51) | < .001 |
| Neuritic plaque density | ||||||
| OLR, POM | – | – | 0.85 (0.73–0.99) | .04 | – | – |
| OLR, PPOM | ||||||
| Sparse | 2.69 (2.21–3.26) | < .001 | – | – | 2.79 (1.95–3.98) | < .001 |
| Moderate | 2.42 (2.07–2.84) | < .001 | – | – | 2.42 (1.88–3.12) | < .001 |
| Frequent | 1.71 (1.55–1.88) | < .001 | – | – | 1.63 (1.41–1.88) | < .001 |
| Lewy pathology stage | ||||||
| BLR | 1.03 (0.93–1.14) | .52 | 1.04 (0.87–1.24) | .66 | 1.45 (1.04–2.03) | .03 |
Results of multinomial, ordinal, and binary logistic regression models for each polygenic score and pathological diagnosis group and outcome variable are displayed. For ordinal logistic regressions, proportional odds models were used except in the case where the proportional odds assumption was violated, in which cases partial proportional odds models were used. Effects are reported per unit increase in the polygenic score. Significance was set to p < .017, Bonferroni corrected for comparisons across the three polygenic scores
Abbreviations: RRR, relative risk ratio; OR, odds ratio; MLR, multinomial logistic regression; OLR, ordinal logistic regression; POM, proportional odds model; PPOM, partial proportional odds model; BLR, binary logistic regression PD, Parkinson’s disease, PRS, polygenic risk score; DLB, dementia with Lewy bodies; AD, Alzheimer’s disease; PHS, polygenic hazard score; FTD, frontotemporal lobar degeneration; MTLS, medial temporal lobe sclerosis