Table 2.
Association of EVTF Activity With Coagulation and Fibrinolysis Markersa
| Markers of coagulation/fibrinolysis | EVTF Activity (ng/L) |
|---|---|
| D-dimer (mg/L) | β = 0.001 P = .983 |
| APTT (s−1) | β = 0.272 P = .359 |
| PT/INR | β = −0.016 P = .11 |
| Fibrinogen (g/L) | β = −0.171 P = .084 |
| Platelets (×109/L) | β = −7.964 P = .106 |
| PAI-1 (ng/mL) | β = 4.889P = .004 |
| tPA (ng/mL) | β = 4.604P = .001 |
Statistical significances are displayed in bold.
Abbreviations: APTT, activated partial thromboplastin time; EVTF, extracellular vesicle tissue factor; PAI-1, plasminogen activator inhibitor 1; PT/INR, prothrombin time converted to international normalized ratio.
aThe association between EVTF activity and coagulation and fibrinolysis markers were analyzed using the generalized estimating equation method. Only time points within 21 days postdisease onset are included in this analysis. The estimated β-coefficients corresponds to the change in dependent variable for 1 unit increase of EVTF.