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. 2020 May 9;222(8):1400–1404. doi: 10.1093/infdis/jiaa251

Figure 2.

Figure 2.

ClpXP is important for survival against host cell killing. A, Intracellular gentamicin protection assay 4 hours post-infection (multiplicity of infection [MOI] = 1) in bone marrow–derived dendritic cells, bone marrow–derived macrophages, and RAW264.7 cells. B, Cells were infected with fluorescently labeled (AF647) Staphylococcus aureus (MOI = 1) for 5 and 30 minutes and phagocytosis was detected by flow cytometry. n = 6 from 2 independent experiments. C, Killing activity of neutrophils 1 hour after incubation (MOI = 1). D, Neutrophil viability was quantified following Trypan blue staining. n = 6 from 2 independent experiments. Graphs display means with standard deviation. *P < .05, **P < .01, and ***P < .001, compared to wild-type. Abbreviations: BMDC, bone marrow–derived dendritic cells; BMM, bone marrow–derived macrophages; UN, uninfected; WT, wild-type.