Table 5.
Demographics at presentation and therapies administered stratified by multisystem inflammatory syndrome in children and adolescents (MIS-C) status. Values are numbers (percentage) unless stated otherwise
| Variable | Did not meet MIS-C criteria (n=404; 88.6%) | Met MIS-C criteria (n=52; 11.4%) | P value* |
|---|---|---|---|
| Median (interquartile range) age, years | 1.6 (0.2 to 12.9) | 10.7 (8.3 to 14.1) | <0.001 |
| Age group, years: | <0.001 | ||
| <1 | 164 (40.6) | 1 (1.9) | |
| 1-4 | 70 (17.3) | 4 (7.7) | |
| 5-9 | 43 (10.6) | 16 (30.8) | |
| 10-14 | 48 (11.9) | 22 (42.3) | |
| 15-19 | 79 (19.6) | 9 (17.3) | |
| Sex at birth: | 1.00 | ||
| Male | 241 (59.7) | 31 (59.6) | |
| Female | 163 (40.3) | 21 (40.4) | |
| Missing | 0 (0.0) | 0 (0.0) | |
| Ethnicity: | 0.004 | ||
| White | 207 (51.2) | 16 (30.8) | |
| Black | 30 (7.4) | 9 (17.3) | |
| South Asian | 44 (10.9) | 4 (7.7) | |
| Other | 74 (18.3) | 16 (30.8) | |
| Missing | 49 (12.1) | 7 (13.5) | |
| White ethnicity: | 0.004 | ||
| No | 148 (36.6) | 29 (55.8) | |
| Yes | 207 (51.2) | 16 (30.8) | |
| Missing | 49 (12.1) | 7 (13.5) | |
| Any comorbidity: | 0.052 | ||
| No/unknown | 227 (56.2) | 37 (71.2) | |
| Yes | 177 (43.8) | 15 (28.8) | |
| Obesity: | 0.005 | ||
| No | 379 (93.8) | 46 (88.5) | |
| Yes | 6 (1.5) | 5 (9.6) | |
| Missing | 19 (4.7) | 1 (1.9) | |
| Immunosuppressant use before presentation†: | 0.60 | ||
| No | 348 (86.1) | 48 (92.3) | |
| Yes | 35 (8.7) | 3 (5.8) | |
| Missing | 21 (5.2) | 1 (1.9) | |
| Admitted >5 days before symptom onset: | 0.014 | ||
| No | 345 (85.4) | 52 (100.0) | |
| Yes | 35 (8.7) | 0 (0.0) | |
| Missing | 24 (5.9) | 0 (0.0) | |
| Intravenous steroid: | <0.001 | ||
| No | 333 (82.4) | 20 (38.5) | |
| Yes | 20 (5.0) | 24 (46.2) | |
| Missing | 51 (12.6) | 8 (15.4) | |
| High flow nasal cannula oxygen: | <0.001 | ||
| No | 343 (84.9) | 29 (55.8) | |
| Yes | 47 (11.6) | 23 (44.2) | |
| Missing | 14 (3.5) | 0 (0.0) | |
| Non-invasive ventilation: | <0.001 | ||
| No | 366 (90.6) | 34 (65.4) | |
| Yes | 31 (7.7) | 18 (34.6) | |
| Missing | 7 (1.7) | 0 (0.0) | |
| Invasive ventilation: | 0.001 | ||
| No | 361 (89.4) | 38 (73.1) | |
| Yes | 36 (8.9) | 14 (26.9) | |
| Missing | 7 (1.7) | 0 (0.0) | |
| Inotropic support: | <0.001 | ||
| No | 362 (89.6) | 24 (46.2) | |
| Yes | 18 (4.5) | 25 (48.1) | |
| Missing | 24 (5.9) | 3 (5.8) | |
| ICU/HDU admission: | <0.001 | ||
| No | 342 (84.7) | 14 (26.9) | |
| Yes | 62 (15.3) | 38 (73.1) | |
| Missing | 0 (0.0) | 0 (0.0) | |
| Outcome: | 0.49 | ||
| Died | 4 (1.0) | 0 (0.0) | |
| Discharged alive | 353 (87.4) | 43 (82.7) | |
| Ongoing care | 37 (9.2) | 8 (15.4) | |
| Palliative discharge | 2 (0.5) | 0 (0.0) | |
| Missing | 8 (2.0) | 1 (1.9) |
HDU=high dependency unit; ICU=intensive care unit.
*
Categorical variables analysed using Fisher’s exact test and continuous variables by Kruskal-Wallis test.
†
Includes oral but not inhaled corticosteroids.