Table 2.
Changes in Outcomes
| Variables | Mean change from baseline (95% CI) |
Between-group difference (95% CI) |
||
|---|---|---|---|---|
| GAD without comorbid affective disorder | GAD with comorbid affective disorder | GAD with comorbid affective disorder versus GAD without comorbid affective disorder | pa | |
| HRSA | 0.75 | |||
| Week 2 | −5.08 (−5.8 to −4.3) | −5.26 (−6.1 to −4.4) | −0.17 (−1.3 to 1.0) | |
| Week 4 | −7.32 (−8.1 to −6.5) | −7.82 (−8.7 to −6.9) | −0.50 (−1.7 to 0.7) | |
| Week 8 | −8.90 (−9.7 to −8.1) | −9.48 (−10.4 to −8.6) | −0.59 (−1.8 to 0.6) | |
| HRSD 17 | 0.14 | |||
| Week 2 | −3.89 (−4.7 to −3.1) | −3.73 (−4.7 to −2.8) | 0.16 (−1.1 to 1.4) | |
| Week 4 | −5.63 (−6.5 to −4.8) | −6.23 (−7.2 to −5.3) | −0.60 (−1.9 to 0.7) | |
| Week 8 | −6.86 (−7.7 to −6.0) | −8.09 (−9.0 to −7.1) | −1.23 (−2.5 to 0.05) | |
| GAD-7 | 0.34 | |||
| Week 2 | −4.78 (−5.6 to −4.0) | −4.65 (−5.5 to −3.8) | 0.12 (−1.1 to 1.3) | |
| Week 4 | −6.26 (−7.1 to −5.4) | −7.15 (−8.1 to −6.2) | −0.89 (−2.1 to 0.3) | |
| Week 8 | −7.54 (−8.4 to −6.7) | −8.05 (−9.0 to −7.1) | −0.50 (−1.7 to 0.7) | |
| HRSD extended core | 0.023 | |||
| Week 2 | −1.15 (−1.6 to −0.7) | −1.23 (−1.7 to −0.7) | −0.075 (−0.7 to 0.6) | |
| Week 4 | −1.68 (−2.1 to −1.2) | −2.32 (−2.8 to −1.8) | −0.64 (−1.3 to 0.03) | |
| Week 8 | −2.19 (−2.6 to −1.7) | −3.10 (−3.6 to −2.6) | −0.90 (−1.6 to −0.2) | |
| BAI | 0.87 | |||
| Week 2 | −4.80 (−6.1 to −3.4) | −4.59 (−6.1 to −3.0) | 0.21 (−1.8 to 2.2) | |
| Week 4 | −7.30 (−8.7 to −5.9) | −7.06 (−8.6 to −5.5) | 0.24 (−1.8 to 2.3) | |
| Week 8 | −8.86 (−10.3 to −7.4) | −9.44 (−11.0 to −7.8) | −0.58 (−2.7 to 1.5) | |
| BDI | 0.060 | |||
| Week 2 | −6.05 (−7.5 to −4.6) | −7.76 (−9.4 to −6.1) | −1.71 (−3.9 to 0.4) | |
| Week 4 | −7.51 (−9.0 to −6.0) | −9.36 (−11.0 to −7.7) | −1.85 (−4.0 to 0.3) | |
| Week 8 | −9.20 (−10.7 to −7.7) | −12.26 (−13.9 to −10.6) | −3.06 (−5.3 to −0.8) | |
All statistical tests were two-sided. Bold indicates statistical significance set at 0.05.
a
Mixed-effect p-value of the interaction term.
CI, confidence interval; HRSA, Hamilton rating scale for anxiety.