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. 2020 Sep 9;22:207. doi: 10.1186/s13075-020-02268-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Pre- and post-treatment patient-related outcome-based cluster analysis. Cluster analysis of study participants by patient reported outcomes (PRO) at baseline and at week 24 (exposed to secukinumab 300 mg). Colors show Z scores with blue indicating the respective patient-related outcome being better than the mean and red indicating the parameter being lower than mean. Baseline clustering by disease type (very early disease vs. established psoriatic arthritis) is lost after secukinumab treatment and replaced by clusters related to the amount of physical and mental disease burden. Left: Baseline cluster showing accumulation of very early disease patients in the upper cluster with milder PROs, while patients with established disease accumulate in the lower cluster with more severe impact of disease. Right: 24 week clusters showing redistribution of very early and established disease among 4 clusters: top: high disease burden in physical and mental PROs, upper: moderate disease burden in physical and mental PROs, lower: low disease burden in physical and mental PROs, bottom: low disease burden in physical and moderate in mental PROs; DLQI, Dermatology Life Quality Index; PsA, psoriatic arthritis; PsAID, Psoriatic Arthritis Impact of Disease; VAS, visual analog scale