Table 2. CLR Potentiation Data against AB5075 Using Phenyl Core Derivatives 6a–b and 10a–e.
| Compound | R1 | R2 | Compound MIC (μM) | Concentration Tested (μM) | CLR MIC (μg/mL) | Fold Reduction |
|---|---|---|---|---|---|---|
| 32 | ||||||
| 6a | OCH3 | H | 100 | 30 | 0.5 | 64 |
| 20 | 4 | 8 | ||||
| 10 | 16 | 2 | ||||
| 6b | H | CH3 | >200 | 30 | 0.5 | 64 |
| 20 | 0.5 | 64 | ||||
| 10 | 8 | 4 | ||||
| 10a | CH3 | H | >200 | 30 | 0.5 | 64 |
| 20 | 1 | 32 | ||||
| 10 | 16 | 2 | ||||
| 10b | Cl | H | >200 | 30 | 16 | 2 |
| 10c | F | H | >200 | 30 | 8 | 4 |
| 10d | H | F | >200 | 30 | 0.25 | 128 |
| 20 | 0.25 | 128 | ||||
| 10 | 0.5 | 64 | ||||
| 7.5 | 4 | 8 | ||||
| 5 | 8 | 4 | ||||
| 10e | H | Cl | >200 | 30 | 0.5 | 64 |
| 20 | 0.5 | 64 | ||||
| 10 | 8 | 4 |