. 2020 Jul 29;11(9):1751–1758. doi: 10.1021/acsmedchemlett.0c00264

Table 3. SAR of Indole N-1 and C-3 Positions.

compd	R₁	R₂	TLR7 IC₅₀ (nM)^a	TLR9 IC₅₀ (nM)^a
5n	H	Me	250 ± 160	430 ± 260
7a	Me	Me	5260 ± 1540	740 ± 170
7b	H	Cl	1880 ± 710	430 ± 170
7c	H	CN	>10 000	260 ± 200
7d	H	CH₂CH₃	130 ± 100	490 ± 370
7e	H	CH₂CF₃	70 ± 40	750 ± 270
7f	H	isopropyl	10 ± 7	700 ± 390
7g	H	isobutyl	1290 ± 770	830 ± 770

IC₅₀ values are a mean of two or more individual determinations.