Table 1.
Clinical characteristics in 779 patients with GEP-NENs
| Variables | Total n = 779 (%) |
|---|---|
| Age at diagnosis (years) | 55 (13–87) |
| Sex | |
| Male | 460 (59.1) |
| Female | 319 (40.9) |
| Primary tumor site | |
| Pancreas | 216 (27.7) |
| Rectum | 208 (26.7) |
| Stomach | 144 (18.5) |
| Esophagus | 44 (5.6) |
| Duodenum | 31 (4.0) |
| Colon | 29 (3.7) |
| Gallbladder | 18 (2.3) |
| Appendix | 11 (1.4) |
| Small intestine | 4 (0.5) |
| Other sites | 74 (9.5) |
| Tumor grade and type | |
| NET G1 | 313 (40.2) |
| NET G2 | 144 (18.5) |
| NET G3 | 4 (0.5) |
| NEC | 270 (34.7) |
| MINEN | 40 (5.1) |
| Unknown | 8 (1.0) |
| aCgA | |
| Positive | 448 (57.5) |
| Negative | 221 (28.4) |
| Unknown | 110 (14.1) |
| aSyn | |
| Positive | 665 (85.4) |
| Negative | 15 (1.9) |
| Unknown | 99 (12.7) |
| Metastasis | 311 (39.9) |
Abbreviations: GEP-NENs gastroenteropancreatic neuroendocrine neoplasms, NET neuroendocrine tumors, NEC neuroendocrine carcinoma, MiNEN mixed neuroendocrine–non-neuroendocrine neoplasm, CgA chromogranin; Syn, synaptophysin. a The expression of CgA or Syn in primary site