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. 2020 Sep 9;19:136. doi: 10.1186/s12933-020-01107-3

Table 2.

MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in endothelial cells (SIRT1)

miRNA Up/downregulation (obesity) Refs. Function Refs. Target Refs.
miR-204 Up [91] EC dysfunction [91] SIRT1 [91]
miR-217 Up [101] Premature cell senescence [98] SIRT1 [98]
miR-34a Up [100] Premature cell senescence [99] SIRT1 [100]
miR-149 Down [103, 105] Regression of atherosclerotic lesions [104] SIRT1 [103]
miR-132 Up [106108] Macrophage infiltration in ECs [106108] SIRT1 [106]