Table 6.
MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in autophagy fusion and degradation machinery
| miRNAs | Up/downregulation (Obesity) | Refs. | Function | Refs. | Target | Refs. |
|---|---|---|---|---|---|---|
| miR-374 | Up | [228] | Deregulating vascular endothelial growth factor receptor-1 signaling | [229] | UVRAG | [227] |
| miR-630 | Up | [231] | Suppresses autophagy | [231] | UVRAG | [227] |
| miR-125 | Up | [255, 256] | EC senescence and atherosclerosis | [255, 256] | UVRAG | [254] |
| miR-351 | Up | [257] | Attenuate EC survival | [257] | UVRAG | [254] |
| miR-23a | Up | [261] | Promotes atherosclerotic plaque formation | [260] | Lamp1 | [258] |
| miR-320a | Up | [262] | Regulates atherogenesis | [263] | Lamp1 | [259] |
| miR-487-5p | Up | [140] | Unknown | – | Lamp2 | [264] |
| miR30c | Down | [268, 269] | EC inflammation | [268, 269] | Rab7 | [267] |
| miR-96 | Up | [241] | EC impairment | [274] | VAMP8 | [271] |
| miR-124 | Up | [273] | EC apoptosis | [275] | STX17 | [272] |