Table 7.
MiRNA regulation during obesity, their function in the cardiovascular system and their potential targets in ER stress pathway
| miRNAs | Up/downregulation (Obesity) | Refs. | Function | Refs. | Target | Refs. |
|---|---|---|---|---|---|---|
| miR-30d | Up | [58] | Unknown | – | GRP78/BIP | [288] |
| miR-181a | Up | [225, 226] | Oxidative stress-induced EC dysfunction | [224] | GRP78/BIP | [288] |
| miR-199a | Up | [184, 188] | EC dysfunction | [185] | GRP78/BIP | [288] |
| miR-204 | Up | [44] | EC dysfunction | [44] | PERK | [289, 290] |
| miR-214 | Up | [294, 295] | Regulates EC function | [294, 295] | ATF 4, XBP1 | [293, 307] |
| miR-663 | Up | [297] | Regulates oscillatory shear in EC- atherosclerosis | [297] | ATF 4 | [296] |
| miR-211 | Up | [301] | Promotes atherosclerosis | [302] | CHOP | [300] |
| miR-1291 | Unknown | – | EC dysfunction | [305, 306] | UPR, IRE1α | [303] |
| miR30c | Down | [268, 269] | EC inflammation | [268, 269] | XBP1 | [308] |
| miR-24 | Up | [58–60] | Exacerbates atherogenesis and plaque formation | [62, 63] | PERK&IRE1 | [309] |
| miR-23a | Up | [261] | Promotes atherosclerotic plaque formation | [260] | PERK&IRE1 | [309] |
| miR-27a | Up | [310] | Atherosclerosis formation | [311] | PERK&IRE1 | [309] |
| miR-221 | Up | [313] | EC dysfunction | [314] | ATF6 | [312] |
| miR-145 | Up | [315] | Promotes atherosclerosis | [317] | ATF6 | [312] |
| miR-494 | Up | [316] | Promotes atherosclerosis | [318, 319] | ATF6 | [312] |