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. 2020 Jun 15;10(8):1521–1533. doi: 10.1016/j.apsb.2020.06.005

Figure 1.

Fig. 1

Characterization of SA-BNRplex. (A) Effect of baicalein-loading on the particle size of BNRs. (B) Effect of mass ratio of CLG/anti-miR 155 on the particle size of BNRplex; effect of SA coating on the (C) particle size and (D) surface zeta potential of SA-BNRplex. (E) Gel electrophoresis assay of BNRplex. (F) TEM image (scale bar = 100 nm) of optimized formulation. Stability against (G) RNase or (H) serum evaluated by agarose gel electrophoresis. Anti-miR155 or SA-BNRplex was incubated with 10% serum solution or 10 μg/mL RNase at 37 °C for different durations. (I) Particle-size change of SA-BNRplex in 10% serum solution. (J) In vitro release of baicalein from SA-BNRplex in buffer solution at pH of 5.0, 6.8, and 7.4 at 37 °C for 24 h (mean ± SD, n = 3). (K) Digital photo of optimized formulation.