Figure 5.

Blood circulation and plaque targeting. (A) Plasma concentration–time curves and (B) pharmacokinetic parameters. DiR-labeled nanorods were injected via the tail vein at the DiR dose of 0.5 mg/kg, according to the body weight (mean ± SD, n = 5). (C) Colocalization of FITC-labeled nanorods and aortas. The artery vessels were collected at 2 h post injection of FITC-labeled nanorods at a FITC dose of 0.25 mg/kg. The nuclei were stained by DAPI (blue). The scale bar is 100 μm. C_max, maximum plasma concentration; AUC, area under the concentration curve; T_max, time to reach Cmax; t_1/2, biological half-life; CL, clearance.