Table 2.

Comparison of the different gene vectors for neurodegenerative disorders.

Vector type	Specific characteristics	Advantage	Disadvantage
AAVs	Numerous AAV serotypes; lack of targeting and site-specific; relative safety profile	Relative stable transgene expression; nonpathogenic; various serotypes available	Immune responses; limited gene packaging capacity
Adv	Adv cannot introduce its gene into the host genome	Lower genotoxicity and insertional mutagenesis	Immune responses; relative transient transgene expression; re-administration; requires receptors for cell uptake
LVs	Retroviruses can integrate DNA payloads into the host genome	Lower frequency of administration; stable and long-term transgene expression	Immune responses; genotoxicity; insertional mutagenesis
Polymer- and lipid-based vectors	Non-viral vectors can be altered to impart desired functionalities	Large-scale production; controlled release; large gene packaging capacity; lower immunogenicity	Cytotoxicity; nonspecific binding and rapid clearance