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. 2019 Dec 16;10(8):1476–1491. doi: 10.1016/j.apsb.2019.12.008

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© 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Inhibition of cell migration and EMT induced by compound 19 in HGC-27 and MGC-803 cells. (A) and (B) Wound healing assay of compound 19 in HGC-27 and MGC-803 cells. (C)–(F) Compound 19 suppressed migration ability of both HGC-27 and MGC-803 cells. (G) Adhesion assay in HGC-27 cells after treatment with compound 19. (H) The expressions of E-Cadherin, N-Cadherin, vimentin and ZEB1 after 48 h treatment of compound 19 in HGC-27 cells using GAPDH as the loading control. ∗P < 0.05 and ∗∗P < 0.01 were considered statistically significant. Data are the mean ± SD. All experiments were performed for three times.