Table 4. Rat Clearance, Tissue Penetration, and Oral Bioavailability.
| Entry | Blood Clb (mL/min/kg) | Brain:Blood ratioa | % F(po) |
|---|---|---|---|
| 20 | 39 | 6.8 | 43 |
| 26 | 91 | 3.5 | 31 |
| 29 | 37 | 0.8 | 39 |
| 37 | 40 | 4.8 | 25 |
a
Total by equilibrium dialysis.
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