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. 2020 Sep 10;12:106. doi: 10.1186/s13195-020-00675-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Representative MR angiographic images of intracranial and neck vessels, and coronal sections of T1-weighted images showing medial temporal structures including the bilateral hippocampi of CI individuals in the a stenosis− group and b stenosis+ group with regard to number of stenotic intracranial arteries ≥ 2. a Stenosis−: MR angiography of a 77-year-old woman with MCI with no steno-occlusive lesions in both intracranial and neck vessels. HVa was − 1052 mm³, and no significant hippocampal atrophy was observed in coronal sections on T1-weighted MRI. b Stenosis+: MR angiography of an 81-year-old woman with MCI with multifocal intracranial arterial stenosis, while no steno-occlusive lesions were found in the extracranial carotid arteries. HVa was − 3862 mm³, and coronal sections on T1-weighted MRI indicate bilateral hippocampal atrophy. MR, magnetic resonance; HVa, hippocampal volume adjusted for intracranial volume; MCI, mild cognitive impairment