Table 1.
Demographic and clinical characteristics of participants
| Variables | CN (N = 281) | CI (N = 199) | p value |
|---|---|---|---|
| Age, years | 69.1 ± 8.1 | 72.9 ± 7.4 | < 0.001* |
| Females | 146 (52.0%) | 134 (67.3%) | 0.001* |
| Education, years | 11.9 ± 4.8 | 9.7 ± 4.9 | < 0.001* |
| APOE4 carriers | 52 (18.5%) | 83 (41.7%) | < 0.001* |
| Global CDR (0/0.5/1) | 281/0/0 | 0/153/46 | < 0.001* |
| CDR-SOB | 0.0 ± 0.1 | 2.7 ± 2.0 | < 0.001* |
| Hypertension | 133 (47.3%) | 99 (49.7%) | 0.602 |
| Diabetes mellitus | 46 (16.4%) | 34 (17.1%) | 0.836 |
| Coronary artery disease | 16 (5.7%) | 10 (5.0%) | 0.470 |
| Hyperlipidemia | 96 (34.2%) | 71 (35.7%) | 0.731 |
| Stroke | 0 (0.0%) | 0 (0.0%) | NA |
| Transient ischemic attack | 2 (0.7%) | 1 (0.5%) | 0.774 |
| Vascular risk factor score | 17.4 ± 16.11 | 18.0 ± 16.8 | 0.679 |
| WMH volume (cm3)a | 5.7 ± 5.3 | 6.4 ± 5.2 | 0.202 |
Data are presented as mean ± SD or n (%)
CN cognitively normal, CI cognitively impaired, MCI mild cognitive impairment, AD dementia, Alzheimer’s dementia, CDR-SOB Clinical Dementia Rating sum of box, WMH white matter hyperintensities
aData for 422 individuals were available (256 CN and 166 CI)
*p < 0.05