Table 2.
Vessel stenosis features and AD biomarkers of participants
| Variables | CN (N = 281) | CI (N = 199) | p value |
|---|---|---|---|
| Large vessel stenosis | |||
| Presence of any detectable stenosis | |||
| Any extracranial carotid stenosis | 23 (8.2%) | 22 (11.2%)a | 0.264 |
| Any intracranial stenosis | 77 (27.4%) | 71 (35.7%) | 0.053 |
| Both extracranial carotid and intracranial stenosis | 12 (4.3%) | 10 (5.0%) | 0.697 |
| Presence of stenosis based on severity threshold | |||
| ≥ 50% intracranial stenosis | 19 (6.8%) | 21 (10.6%) | 0.139 |
| Number of stenotic intracranial arteries ≥ 2 | 44 (15.7%) | 38 (19.1%) | 0.324 |
| Presence of stenosis according to location | |||
| Anterior circulation stenosis | 69 (24.6%) | 61 (30.7%) | 0.139 |
| Posterior circulation stenosis | 21 (7.5%) | 21 (10.6%) | 0.239 |
| AD biomarkers | |||
| Global Aβ deposition (SUVR) | 1.184 ± 0.239 | 1.621 ± 0.156 | < 0.001* |
| Aβ positivity | 39 (13.9%) | 112 (56.3%) | < 0.001* |
| Neurodegeneration biomarkers | |||
| AD-CT (mm) | 2.866 ± 0.174 | 2.584 ± 0.286 | < 0.001* |
| HVa (mm3) | − 759 ± 838 | − 2132 ± 1219 | < 0.001* |
Data are presented as mean ± SD or n (%)
CN cognitively normal, CI cognitively impaired, AD-CT Alzheimer’s disease-signature cortical thickness, HVa hippocampal volume adjusted for intracranial volume
aAmong CI group, data for 196 individuals were available
*p < 0.05