Table 4.

Confirmatory multivariable analyses for the association between extracranial carotid and intracranial arterial stenosis and neurodegeneration biomarkers in the CN group

AD biomarker	Variables	Type of stenosis	B	SE	p
Neurodegeneration biomarker	AD-CT	Any extracranial carotid stenosis	− 0.051	0.033	0.121
		Any intracranial stenosis	− 0.033	0.020	0.104
		Number of stenotic intracranial arteries ≥ 2	− 0.040	0.025	0.113
		Anterior circulation	− 0.024	0.021	0.254
		Posterior circulation	− 0.074	0.034	0.030*
	HVa	Any intracranial stenosis	− 30.760	95.491	0.748

Covariates for confirmatory multivariable analyses include age, sex, and APOE4 carrier status. Units for AD biomarker variables are as follows: SUVR for global Aβ, mm for AD-CT, and mm³ for HVa. When Bonferroni-corrected p value (p < 0.05/6 = 0.008) was applied for confirmatory multivariable analyses regarding neurodegeneration biomarkers, these associations were not significant, although posterior circulation stenosis showed a trend for association with reduced AD-CT

AD Alzheimer’s disease, CN cognitively normal, SE standard error, AD-CT Alzheimer’s disease-signature cortical thickness, HVa hippocampal volume adjusted for intracranial volume

^aNo significant findings in the exploratory univariable analyses step regarding Aβ biomarker

*p < 0.05 (before Bonferroni correction)