Table 6.

Confirmatory multivariable analyses for the association between extracranial carotid and intracranial arterial stenosis and HVa in the CI group

AD biomarker	Variables	Type of stenosis	B	SE	p
Neurodegeneration biomarker	HVa	Any intracranial stenosis	− 84.119	158.679	0.597
		Number of stenotic intracranial arteries ≥ 2	− 428.816	184.921	0.021*†

Covariates for confirmatory multivariable analyses include age, sex, APOE4 carrier status, and clinical diagnosis (mild cognitive impairment or AD dementia). Units for AD biomarker variables are as follows: SUVR for global Aβ, mm for AD-CT, and mm³ for HVa. When Bonferroni-corrected p value was applied for confirmatory multivariable analyses regarding neurodegeneration biomarkers, the association between presence of number of stenotic intracranial arteries ≥ 2 and lower HVa in the CI group remained significant

AD Alzheimer’s disease, CI cognitively impaired, SE standard error, SUVR standardized uptake value ratio, HVa hippocampal volume adjusted for intracranial volume

^aNo significant findings in the exploratory univariable analyses step regarding Aβ biomarker and AD-CT

*p < 0.05 (before Bonferroni correction)

^†p < 0.025 (Bonferroni-corrected p < 0.05/2 = 0.025 was used as a statistical threshold)